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gnas  (Bioscientifica Ltd)

 
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    Bioscientifica Ltd gnas
    Gnas, supplied by Bioscientifica Ltd, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/gnas/product/Bioscientifica Ltd
    Average 86 stars, based on 1 article reviews
    gnas - by Bioz Stars, 2026-06
    86/100 stars

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    siRNA sequence and chemical structures of mononucleotides (A) Schematic of the parent siRNA duplex targeting human PCSK9. This siRNA was previously characterized. (B) Structures of 2′-OMe, 2′-F, ( S )-GNA, natural phosphate, and phosphorothioate linkages. (C) Structures of 2′-modified mononucleotides used in this study.

    Journal: Molecular Therapy. Nucleic Acids

    Article Title: 2′-Ribose-modified nucleotides: A strategy for reducing off-target effects of oligonucleotide drugs

    doi: 10.1016/j.omtn.2026.102835

    Figure Lengend Snippet: siRNA sequence and chemical structures of mononucleotides (A) Schematic of the parent siRNA duplex targeting human PCSK9. This siRNA was previously characterized. (B) Structures of 2′-OMe, 2′-F, ( S )-GNA, natural phosphate, and phosphorothioate linkages. (C) Structures of 2′-modified mononucleotides used in this study.

    Article Snippet: To address this issue, Alnylam Pharmaceuticals has employed GNA modification at position 7 of the siRNA antisense strand to disrupt the seed region, thereby significantly reducing off-target effects and alleviating hepatocellular toxicity.

    Techniques: Sequencing, Modification